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Total 6408 results found since Jan 2013.
Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies
The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: ‘platelet-rich fibrin’, ‘intrabony’, ‘periodontal’, ‘bone defect’ and ‘guided tissue regeneration’. A secondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being inc luded. In majority of studies, PRF res...
Source: Tissue Engineering and Regenerative Medicine - September 13, 2017 Category: Biotechnology Source Type: research
In search of the mechanisms of metformin in cancer
In search of the mechanisms of metformin in cancer, Published online: 26 September 2018; doi:10.1038/s41574-018-0104-3In search of the mechanisms of metformin in cancer
Source: Nature Reviews Endocrinology - September 26, 2018 Category: Endocrinology Authors: Alan Morris Source Type: research
Instead of FaceBook, I'll be Posting Diabetes Tidbits in the Comment Section of Monthly Posts
I've had it with FaceBook. I can't control the ads they show people who come to my page, which are invariably for scams that prey on people with diabetes. I'm tired of channeling a steady flow of people with diabetes into the greedy hands of FaceBooks's abusive advertisers. Even worse, after I had recruited 1700+ people to my FB page, FB stopped showing most of them my updates, telling me I'd have to pay upwards of $100 each time I posted if I wanted the people who had subscribed to my page to see these updates. FaceBook's belief that they have a right to spam people who like my page with damaging ads while withholding the...
Source: Diabetes Update - March 11, 2013 Category: Diabetes Authors: Jenny Source Type: blogs
Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database
rman
& S J Freedland
Source: Prostate Cancer and Prostatic Diseases - October 8, 2013 Category: Urology & Nephrology Authors: E H AllottM R AbernL GerberC J KetoW J AronsonM K TerrisC J KaneC L AmlingM R CooperbergP G MoormanS J Freedland Tags: metformin diabetes biochemical recurrence outcomes Source Type: research
Using Age-Related Gene Expression Changes to Search for Drugs to Slow Aging
In this study, using gene expression data for human brain ageing, we aimed to discover not only new pro-longevity drugs but also those that can improve health during ageing. The biological processes showing a change in expression include pathways related to synaptic and cognitive functions as well as proteostasis, suggesting gene expression changes in the ageing brain could be used as a surrogate to find drugs to target detrimental effects.
Using multiple gene expression datasets from brain tissue, taken from patients of different ages, we first identified the expression changes that characterise ageing. Then, we c...
Source: Fight Aging! - July 2, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Search list of recalled metformin products
Source: FDA Center for Drug Evaluation and Research - What's New - July 13, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
AZ at it again
AUTH/2793/9/15 - Clinical pharmacist v AstraZenecaCase number:AUTH/2793/9/15Case ref:Clinical pharmacist v AstraZenecaDescription:Identifying patients suitable for Forxiga treatment and failing to provide an accurate response to the PanelNo breach:No breaches Clauses 2 and 7.2Breach:Breaches Clauses 3.2, 7.2 and 9.1. Corrective statement and public reprimand.Appeal:No appealReview:Published in the May 2016 ReviewReceived:10/09/2015Completed:17/03/20162793Case Summary:A clinical pharmacist complained about an AstraZeneca leavepiece about how to create a clinical system search to identify patients suitable for tr...
Source: PharmaGossip - September 27, 2016 Category: Pharmaceuticals Authors: insider Source Type: blogs
Law and Order? - Bristol-Myers-Squibb Settles Case Alleging Fraud and Kickbacks, No Admissions of Guilt, No Individuals Charged
Introduction Donald Trump, Republican candidate for the US presidency last week announced he is the " law and order " candidate, accompanied by then vice presidential contender and New Jersey Governor Chris Christie. I wonder if all this interest in law and order will lead to increasing the effectiveness of enforcing laws when large US health care corporations are accused? For years, we have been watching a parade of legal settlements made by big US health care organizations. These have included the biggest drug companies, biotechnology companies, device companies, insurance companies, etc, etc. ...
Source: Health Care Renewal - July 21, 2016 Category: Health Management Tags: Abilify Bristol-Myers-Squibb crime impunity kickbacks legal settlements logical fallacies Source Type: blogs
Fight Aging! Newsletter, July 9th 2018
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - July 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 2nd 2019
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications.
To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence?
https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/
Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - December 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 5th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 4, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The effect of metformin on aminotransferase levels, metabolic parameters and body mass index in nonalcoholic fatty liver disease patients: a meta-analysis
CONCLUSION: Compared to the controls, metformin can effectively reduce the serum fasting glucose and insulin levels and the HOMA-IR index in NAFLD patients at the 6-month follow-up and ALT and the HOMA-IR index at the 12-month follow-up.PMID:33719959 | DOI:10.2174/1381612827666210315144821
Source: Current Pharmaceutical Design - March 15, 2021 Category: Drugs & Pharmacology Authors: Haibo Hu Junjie Wang Xi Li Lujun Shen Danhe Shi Juanjuan Meng Source Type: research
An integrative review of interventions for limiting gestational weight gain in pregnant women who are overweight or obese
CONCLUSION: The literature suggests a need for longer duration of behavioural lifestyle intervention sessions led by the same midwife trained in motivational interviewing to limit weight gain in pregnant women who are overweight or obese.PMID:33958291 | DOI:10.1016/j.wombi.2021.04.009
Source: Women Birth - May 7, 2021 Category: Midwifery Authors: Wintnie Aung Lauren Saw Linda Sweet Source Type: research
